Name: MOTS-C
Brand: Vial Labs
SKU: MS10
Price: 44.99 EUR
Availability: InStock

Question 1

What is MOTS-c?

Accepted Answer

A 16-amino-acid peptide encoded in the 12S rRNA region of mitochondrial DNA, part of the mitochondrial-derived peptide family.

Question 2

What makes it unusual?

Accepted Answer

It is written into mitochondrial rather than nuclear DNA, and it signals in the opposite direction to most molecules — moving into the nucleus to influence gene expression.

Question 3

How does it activate AMPK?

Accepted Answer

Indirectly. Published work reports that it interferes with the folate–purine pathway, causing AICAR to accumulate, and AICAR activates AMPK.

Question 4

When was it discovered?

Accepted Answer

It was first described in 2015, which makes the literature around it comparatively young.

Question 5

Is there human research?

Accepted Answer

Human work to date is observational, chiefly on circulating levels and age. The interventional literature is preclinical, and the peptide is not approved anywhere.

Question 6

What documentation comes with it?

Accepted Answer

A batch certificate of analysis with HPLC purity, linked on this page and verifiable on the testing laboratory's site.